Ethylenediamine → HCID 89825998, compound

HRID 631812Notes

Reaction equation

HRID 631812 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4](F)[N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:16]([NH2:19])[CH2:17][NH2:18]>>[Br:1][C:2]1[N:3]=[C:4]([NH:18][CH2:17][CH2:16][NH2:19])[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

4

Reactant 3

HCID 3301EthylenediamineHCID 11430Potassium CarbonateHCID 299193662-Bromo-6-fluoro-4-methylpyridine

Product 1

HCID 89825998HCID 89825998, compound

Procedure

To 2-bromo-6-fluoro-4-methyl-pyridine (380 mg, 2 mmol) was added potassium carbonate (552 mg, 4 mmol) followed by ethylenediamine (3 ml) and the resulting mixture was stirred art room temperature for two hours. The mixture was filtered through kieselguhr and the filtrate was evaporated to dryness under reduced pressure to yield 256 mg (1.11 mmol, 56%) MS(ESI) m/z=230.0 [M+1]+.

Workup

  1. filtrationThe mixture was filtered through kieselguhr
  2. customthe filtrate was evaporated to dryness under reduced pressure
  3. customto yield 256 mg (1.11 mmol, 56%)

Sources & evidence

ORD record
ord-10fa4ad627974de8865b7f4dd16a38d7
Source dataset
uspto-grants-2016_04
Patent number
US09321724B2

Reaction notes

Loading…