Hydrochloric Acid → 7-(4-Methyl-2-pyridyl)-2,7-diazaspiro[4.5]decane dihydrochloride

HRID 631821Notes

Reaction equation

HRID 631821 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:24][CH2:23][CH2:22][C:10]3([CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]3)[CH2:9]2)[CH:3]=1.[ClH:25]>CO>[ClH:25].[ClH:25].[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:24][CH2:23][CH2:22][C:10]3([CH2:14][NH:13][CH2:12][CH2:11]3)[CH2:9]2)[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131735428tert-Butyl 7-(4-methyl-2-pyridyl)-2,7-diazaspiro[4.5]decane-2-carboxylate

Product 1

HCID 898257327-(4-Methyl-2-pyridyl)-2,7-diazaspiro[4.5]decane dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The residue of step A was dissolved in a mixture of methanol and hydrochloric acid (4M in dioxane, 5 ml) and stirred at room temperature overnight. The mixture was concentrated under reduced pressure to yield 79 mg of a solid (quantitive) that was used directly in the next step.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-aa29c20d796d4251b8f1d8d882a85f45
Source dataset
uspto-grants-2016_04
Patent number
US09321724B2

Reaction notes

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