反应详情

tert-Butyl-2-(5-methyl-1,2,4-oxadiazol-3-yl)propan-2-ylcarbamate (5.38 g) was dissolved in in ethyl acetate (30 mL) saturated with hydrochloride and stirred at room temperature for 1 h. Then water (50 mL) was added. The aqueous phase was washed with ethyl acetate (2×30 mL) and the pH adjusted with 1 M sodium hydroxide solution to 9˜10. The solution was extracted with ethyl acetate (2×30 mL). The combined extracts were washed with brine and dried over anhydrous sodium sulfate. Removal of the solvent under reduced pressure left the title compound (1.7 g, 54%) as colorless oil; MS: m/e 142.2 [M+H]+.

1. washThe aqueous phase was washed with ethyl acetate (2×30 mL)
2. extractionThe solution was extracted with ethyl acetate (2×30 mL)
3. washThe combined extracts were washed with brine
4. dry with materialdried over anhydrous sodium sulfate
5. customRemoval of the solvent under reduced pressure
6. waitleft the title compound (1.7 g, 54%) as colorless oil