Potassium Carbonate → tert-butyl N-[(1Z,2S)-1-amino-3-cyclopropyl-1-hydroxyiminopropan-2-yl]carbamate

HRID 632028Notes

Reaction equation

HRID 632028 reaction equation
C(=O)([O-])[O-].[K+].[K+].Cl.[NH2:8][OH:9].[C:10]([C@@H:12]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH2:13][CH:14]1[CH2:16][CH2:15]1)#[N:11]>O.C(O)C>[NH2:11]/[C:10](=[N:8]\[OH:9])/[C@@H:12]([NH:17][C:18](=[O:24])[O:19][C:20]([CH3:21])([CH3:23])[CH3:22])[CH2:13][CH:14]1[CH2:16][CH2:15]1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 71087345(S)-tert-Butyl 1-cyano-2-cyclopropylethylcarbamate

Product 1

HCID 89262365tert-butyl N-[(1Z,2S)-1-amino-3-cyclopropyl-1-hydroxyiminopropan-2-yl]carbamateYield 94%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Potassium carbonate (2.18 g, 16 mmol) was dissolved in water (8 mL) and hydroxylamine hydrochloride (1.1 g, 16 mmol) was added. A solution of (S)-tert-butyl 1-cyano-2-cyclopropylethylcarbamate (3.31 g, 16 mmol) in ethanol (24 mL) was added thereto and the resulting reaction mixture was stirred for 72 h. After evaporation of solvents, the residue was dissolved with ethyl acetate (20 mL) and then filtered. The filtrate was concentrated to yield crude product as yellow solid (3.61 g, 94%); MS (EI): m/e 244.2 [M+H]+.

Workup

  1. customthe resulting reaction mixture
  2. customAfter evaporation of solvents
  3. dissolutionthe residue was dissolved with ethyl acetate (20 mL)
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-17dc45010a4d4e0aa21ef2038b89542e
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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