tert-Butyl 3-(methylcarbamoyl)pentan-3-ylcarbamate → 2-Amino-2-ethyl-N-methyl-butyramide

HRID 632079Notes

Reaction equation

HRID 632079 reaction equation
[CH3:1][NH:2][C:3]([C:5]([NH:10]C(=O)OC(C)(C)C)([CH2:8][CH3:9])[CH2:6][CH3:7])=[O:4]>Cl.C(OCC)(=O)C>[NH2:10][C:5]([CH2:8][CH3:9])([CH2:6][CH3:7])[C:3]([NH:2][CH3:1])=[O:4]

Participants

4

Reactant 1

HCID 86674754tert-Butyl 3-(methylcarbamoyl)pentan-3-ylcarbamate

Product 1

HCID 798103702-Amino-2-ethyl-N-methyl-butyramideYield 75%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of tert-butyl 3-(methylcarbamoyl)pentan-3-ylcarbamate (0.18 g, 0.74 mmol) in 10 ml saturated hydrochloride in ethyl acetate was stirred for 60 min at room temperature. Then the solution was evaporated to dryness to obtain the product (80 mg, 75%) as a light yellow solid; MS (LC/MS): 145.2 [M+H]+.

Workup

  1. customThen the solution was evaporated to dryness

Sources & evidence

ORD record
ord-c87266b78f9b4f709056706310a5c905
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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