Hydrochloric Acid → 2-(1,2,4-Oxadiazol-3-yl)propan-2-amine hydrochloride

HRID 632083Notes

Reaction equation

HRID 632083 reaction equation
[O:1]1[CH:5]=[N:4][C:3]([C:6]([NH:9]C(=O)OC(C)(C)C)([CH3:8])[CH3:7])=[N:2]1.[ClH:17]>C(OCC)(=O)C>[ClH:17].[CH3:7][C:6]([NH2:9])([C:3]1[N:4]=[CH:5][O:1][N:2]=1)[CH3:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 73357654tert-butyl N-[2-(1,2,4-oxadiazol-3-yl)propan-2-yl]carbamate

Product 1

HCID 866747552-(1,2,4-Oxadiazol-3-yl)propan-2-amine hydrochlorideYield 94%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl 2-(1,2,4-oxadiazol-3-yl)propan-2-ylcarbamate (0.668 g, 2.9 mmol) was dissolved in in ethyl acetate saturated with hydrochloride (10 mL) and stirred at room temperature for 0.5 h. Then it was concentrated to give product (0.45 g, 94%); MS (EI): m/e=128.2 [M+H]+.

Workup

  1. concentrationThen it was concentrated

Sources & evidence

ORD record
ord-60aba888a71a439d9c8060bbefb7bf3b
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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