反应详情

To a stirred solution of 3-bromo-4-hydroxybenzoic acid (0.5 g) and DMF (0.1 ml) in DCM (10 ml) was added dropwise oxalyl chloride (0.6 ml). After stirring for 2 h, ammonia gas was purged through. After completion of reaction by tlc, the solvent was removed under reduced pressure. The residue was dissolved in water and extracted with ethyl acetate. The organics were dried over sodium sulphate and concentrated in vacuo to yield the title compound, 0.18 g

1. customammonia gas was purged through
2. customAfter completion of reaction by tlc
3. customthe solvent was removed under reduced pressure
4. dissolutionThe residue was dissolved in water
5. extractionextracted with ethyl acetate
6. dry with materialThe organics were dried over sodium sulphate
7. concentrationconcentrated in vacuo