Hydrogen chloride-ethyl acetate → HCID 118061048, compound

HRID 632774Notes

Reaction equation

HRID 632774 reaction equation
[CH3:1][C:2]1([CH3:41])[CH2:6][CH2:5][N:4]([C:7]2[C:11]([NH:12][C:13]([C:15]3[N:16]=[C:17]([C:20]4[CH:25]=[CH:24][N:23]=[C:22]([N:26]([CH2:34][C:35]([F:38])([F:37])[F:36])C(=O)OC(C)(C)C)[CH:21]=4)[O:18][CH:19]=3)=[O:14])=[CH:10][N:9]([CH3:39])[N:8]=2)[C:3]1=[O:40].C(OC(=O)C)C.[ClH:48]>CO.C(OCC)(=O)C>[ClH:48].[CH3:1][C:2]1([CH3:41])[CH2:6][CH2:5][N:4]([C:7]2[C:11]([NH:12][C:13]([C:15]3[N:16]=[C:17]([C:20]4[CH:25]=[CH:24][N:23]=[C:22]([NH:26][CH2:34][C:35]([F:36])([F:38])[F:37])[CH:21]=4)[O:18][CH:19]=3)=[O:14])=[CH:10][N:9]([CH3:39])[N:8]=2)[C:3]1=[O:40]

Participants

5

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 131735455HCID 131735455, compound

Product 1

HCID 118061048HCID 118061048, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of tert-butyl (4-(4-((3-(3,3-dimethyl-2-oxopyrrolidin-1-yl)-1-methyl-1H-pyrazol-4-yl)carbamoyl)-1,3-oxazol-2-yl)pyridin-2-yl)(2,2,2-trifluoroethyl)carbamate (280 mg) and 4M hydrogen chloride ethyl acetate solution (4.0 mL) in methanol (1.0 mL) was stirred at room temperature for 3 hr. The reaction mixture was diluted with ethyl acetate (3.0 mL), and the precipitated solid was collected by filtration, washed with ethyl acetate, and dried under reduced pressure to give the title compound (195 mg).

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. washwashed with ethyl acetate
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-773bb6d0cd3e45848cc957487b10e303
Source dataset
uspto-grants-2016_04
Patent number
US09321757B2

Reaction notes

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