Ethyl Acetate → HCID 118061508, compound

HRID 632812Notes

Reaction equation

HRID 632812 reaction equation
C(OC([NH:8][C:9]1[C:10]([N:15]2[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[C:16]2=[O:27])=[N:11][N:12]([CH3:14])[CH:13]=1)=O)(C)(C)C.C(OCC)(=O)C.CO.[ClH:36]>>[ClH:36].[NH2:8][C:9]1[C:10]([N:15]2[CH2:19][CH2:18][NH:17][C:16]2=[O:27])=[N:11][N:12]([CH3:14])[CH:13]=1

Participants

4

Reactant 3

HCID 8857Ethyl AcetateHCID 21893726Hydrochloride methanolHCID 118061221HCID 118061221, compound

Product 1

HCID 118061508HCID 118061508, compound

Conditions

Temperature
60 °C

Procedure

tert-Butyl 3-(4-((tert-butoxycarbonyl)amino)-1-methyl-1H-pyrazol-3-yl)-2-oxoimidazolidine-1-carboxylate (7.61 g) was dissolved in 2M hydrogen chloride methanol solution (50 mL), and the mixture was stirred at 60° C. for 3 hr. The reaction mixture was ice-cooled, ethyl acetate (50 mL) was added thereto, and the precipitate was collected by filtration, and dried under reduced pressure to give the title compound (4.15 g).

Workup

  1. temperaturecooled
  2. filtrationthe precipitate was collected by filtration
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-761606f9be1a4702b313cc698ded2094
Source dataset
uspto-grants-2016_04
Patent number
US09321757B2

Reaction notes

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