2-Amino-4-methylpyridine → 5-Iodo-4-methylpyridin-2-amine

HRID 632880Notes

Reaction equation

HRID 632880 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.C1C(=O)N([I:16])C(=O)C1>>[I:16][C:7]1[C:2]([CH3:1])=[CH:3][C:4]([NH2:8])=[N:5][CH:6]=1

Participants

3

Reactant 2

HCID 15332-Amino-4-methylpyridineHCID 120273N-Iodosuccinimide

Product 1

HCID 177501955-Iodo-4-methylpyridin-2-amine

Procedure

The title compound is synthesized according to general procedure GP1 starting from 2.0 g (18 mmol) 4-methyl-pyridin-2-ylamine and 4.2 g (18 mmol) NIS. Yield after precipitation from the reaction mixture: 3.6 g (83%).

Workup

  1. customYield
  2. customafter precipitation from the reaction mixture

Sources & evidence

ORD record
ord-1c3b09e1bb1249c1a40a7f012db1d4db
Source dataset
uspto-grants-2016_04
Patent number
US09321771B2

Reaction notes

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