HCID 86704523, compound → HCID 89863747, compound

HRID 633429Notes

Reaction equation

HRID 633429 reaction equation
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]2[O:8][CH2:9][C:10]3([C:13]4[N:14]([N:15]=[N:16][N:17]=4)[C:6]=2[CH:5]=1)[CH2:12][O:11]3)([O-])=O>CCO.[OH-].[OH-].[Pd+2]>[NH2:1][C:4]1[CH:19]=[CH:18][C:7]2[O:8][CH2:9][C:10]([CH3:12])([OH:11])[C:13]3[N:14]([N:15]=[N:16][N:17]=3)[C:6]=2[CH:5]=1

Participants

4

Reactant 1

HCID 86704523HCID 86704523, compound

Product 1

HCID 89863747HCID 89863747, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

The general hydrogenation procedure described herein was used with 9-nitro-5H-spiro[benzo[b]tetrazolo[1,5-d][1,4]oxazepine-4,2′-oxirane] (16 mg, 0.06 mmol) and Pd(OH)2 on carbon (3 mg), at 1 atm H2 (Balloon) in EtOH (15 mL) to give the product (yield assumed quantitative=14 mg).

Workup

  1. customto give
  2. customthe product (yield assumed quantitative=14 mg)

Sources & evidence

ORD record
ord-f073c9c3b88f4be482e65df524adfca9
Source dataset
uspto-grants-2016_04
Patent number
US09321763B2

Reaction notes

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