反应详情

Knochel-Hauser reagent (2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex) is added to a mixture of 2-(cyclohexylmethoxy)pyrimidine in THF at −78° C., stirred for 15 min, then DMF is added. The reaction mixture is stirred at −30° C., quenched by aqueous NH4Cl, extracted with ethyl acetate. Combined organic layers are dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 2-(cyclohexylmethoxy)-pyrimidine-4-carbaldehyde.

1. stirringThe reaction mixture is stirred at −30° C.
2. customquenched by aqueous NH4Cl
3. extractionextracted with ethyl acetate
4. dry with materialCombined organic layers are dried over anhydrous Na2SO4
5. concentrationconcentrated under reduced pressure