Hydrochloric Acid → HCID 90416278, compound

HRID 633607Notes

Reaction equation

HRID 633607 reaction equation
[F:1][C:2]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][S:12]([CH2:15][CH3:16])(=[O:14])=[O:13])=[CH:7][C:6]=1[C:17]1[C:25]2[C:20](=[C:21]([O:29]C)[N:22]=[C:23]([C:26]([OH:28])=[O:27])[CH:24]=2)[N:19]([CH3:31])[CH:18]=1.Cl>O1CCOCC1>[F:1][C:2]1[CH:35]=[C:34]([F:36])[CH:33]=[CH:32][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][S:12]([CH2:15][CH3:16])(=[O:14])=[O:13])=[CH:7][C:6]=1[C:17]1[C:25]2[CH:24]=[C:23]([C:26]([OH:28])=[O:27])[NH:22][C:21](=[O:29])[C:20]=2[N:19]([CH3:31])[CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90416675HCID 90416675, compound

Product 1

HCID 90416278HCID 90416278, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of Example 187E (335 mg, 0.647 mmol), 4M hydrogen chloride in dioxane (2.0 mL, 8.00 mmol) and dioxane (10 mL) was stirred at 75° C. for 4 hours. The reaction mixture was cooled to ambient temperature and was concentrated to dryness. The residue was dried (in-vacuo) to provide 315 mg (97%) of the title compound.

Workup

  1. concentrationwas concentrated to dryness
  2. customThe residue was dried (in-vacuo)

Sources & evidence

ORD record
ord-83cf4607875d4f82bf55ca86a8b4deea
Source dataset
uspto-grants-2016_04
Patent number
US09321764B2

Reaction notes

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