反应详情

温度

70 °C

At room temperature, 45.95 g of N-(4,6-dihydroxy-2-methylsulfanylpyrimidin-5-yl)-4-methoxy-3,5-dimethylbenzamide were suspended with stirring in 125 ml of phosphorus oxychloride, and the mixture was heated at 70° C. for 36 hours. After cooling, the reaction mixture was sucked through a glass frit, giving a yellow solid which was introduced with stirring into a saturated aqueous sodium bisulfate solution and stirred for 10 min. The solid was then filtered off with suction, washed until neutral and dried. This gave 10.47 g (22%) of the title compound, which was reacted further without any further purification.

1. customAt room temperature
2. temperatureAfter cooling
3. customgiving a yellow solid which
4. additionwas introduced
5. filtrationThe solid was then filtered off with suction
6. washwashed until neutral and
7. customdried
8. customThis gave 10.47 g (22%) of the title compound, which was reacted further without any further purification