反应详情

温度

60 °C

7.46 g of potassium carbonate were added to a solution of 4.34 g of 4-(7-chloro-5-methylsulfanyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenol in 45 ml of dimethylformamide, and 2.90 g of tert-butyl bromoacetate were then added. The mixture was stirred at 60° C. for 1 h. The cooled reaction mixture was then added to ice water, and the precipitated solid was filtered off with suction and washed with water. The solid was taken up in dichloromethane and dried over sodium sulfate, activated carbon was added and the mixture was filtered and concentrated under reduced pressure. This gave 4.20 g (71%) of the title compound, which was reacted further without any further purification.

1. additionwere then added
2. customThe cooled reaction mixture
3. filtrationthe precipitated solid was filtered off with suction
4. washwashed with water
5. dry with materialdried over sodium sulfate, activated carbon
6. additionwas added
7. filtrationthe mixture was filtered
8. concentrationconcentrated under reduced pressure
9. customThis gave 4.20 g (71%) of the title compound, which was reacted further without any further purification