Trifluoroacetic acid → HCID 71203152, compound

HRID 633618Notes

Reaction equation

HRID 633618 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:44]=[CH:43][C:42]([F:45])=[CH:41][C:10]=1[O:11][C:12]1[N:13]=[C:14]([CH2:38][CH2:39][CH3:40])[C:15]2[N:20]=[C:19]([C:21]3[CH:35]=[C:34]([CH3:36])[C:24]([O:25][CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])=[C:23]([CH3:37])[CH:22]=3)[O:18][C:16]=2[N:17]=1>ClCCl>[F:8][C:9]1[CH:44]=[CH:43][C:42]([F:45])=[CH:41][C:10]=1[O:11][C:12]1[N:13]=[C:14]([CH2:38][CH2:39][CH3:40])[C:15]2[N:20]=[C:19]([C:21]3[CH:22]=[C:23]([CH3:37])[C:24]([O:25][CH2:26][C:27]([OH:29])=[O:28])=[C:34]([CH3:36])[CH:35]=3)[O:18][C:16]=2[N:17]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71186588HCID 71186588, compound

Product 1

HCID 71203152HCID 71203152, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

55 μl of trifluoroacetic acid were added to a solution of 39 mg of tert-butyl {-4-[5-(2,5-difluorophenoxy)-7-propyloxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}acetate in 0.4 ml of dichloromethane, and the mixture was stirred at room temperature for 16 h. The reaction was then concentrated under reduced pressure, and the residue was triturated with diisopropyl ether, filtered off with suction and dried. This gave 21 mg (60%) of the title compound.

Workup

  1. concentrationThe reaction was then concentrated under reduced pressure
  2. customthe residue was triturated with diisopropyl ether
  3. filtrationfiltered off with suction
  4. customdried

Sources & evidence

ORD record
ord-3e39ee784a6e47efa14faa5f537aa9d6
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

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