HCID 178490493, compound → HCID 178489872, compound

HRID 633630Notes

Reaction equation

HRID 633630 reaction equation
[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][C:7]2[N:12]=[C:11]([OH:13])[C:10]([NH:14][C:15](=O)[C:16]3[CH:21]=[C:20]([CH3:22])[C:19]([O:23][CH3:24])=[C:18]([CH3:25])[CH:17]=3)=[C:9]([OH:27])[N:8]=2)=[CH:4][CH:3]=1>P(Cl)(Cl)(Cl)=O>[Cl:1][C:2]1[CH:29]=[CH:28][C:5]([CH2:6][C:7]2[N:12]=[C:11]([OH:13])[C:10]3[N:14]=[C:15]([C:16]4[CH:21]=[C:20]([CH3:22])[C:19]([O:23][CH3:24])=[C:18]([CH3:25])[CH:17]=4)[O:27][C:9]=3[N:8]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 178490493HCID 178490493, compound

Product 1

HCID 178489872HCID 178489872, compound

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideSolvent

Procedure

40 g of N-[2-(4-chlorobenzyl)-4,6-dihydroxypyrimidin-5-yl]-4-methoxy-3,5-dimethylbenzamide and 150 ml of phosphorus oxychloride were heated at 70° C. for 1.5 h. The mixture was then allowed to cool. The solid formed was filtered off with suction, washed with diethyl ether and dried. This gave 21.1 g (55%) of the title compound.

Workup

  1. temperatureto cool
  2. customThe solid formed
  3. filtrationwas filtered off with suction
  4. washwashed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-78ca153d5cc245729b06efa558e80960
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

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