Hydrochloric Acid → 2-Amino-7-(2-cyano-benzyl)-1,7-dihydro-purin-6-one

HRID 633678Notes

Reaction equation

HRID 633678 reaction equation
O.[C@@H]1([N:11]2[C:21]3[N:20]=[C:18]([NH2:19])[NH:17][C:15](=[O:16])[C:14]=3[N:13]=[CH:12]2)O[C@H](CO)[C@@H](O)[C@H]1O.[C:22]([C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH2:26]Br)#[N:23].Cl>CS(C)=O>[NH2:19][C:18]1[NH:17][C:15](=[O:16])[C:14]2[N:13]([CH2:26][C:25]3[CH:28]=[CH:29][CH:30]=[CH:31][C:24]=3[C:22]#[N:23])[CH:12]=[N:11][C:21]=2[N:20]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 895992-(Bromomethyl)benzonitrileHCID 135705230Guanosine Hydrate

Product 1

HCID 1360655872-Amino-7-(2-cyano-benzyl)-1,7-dihydro-purin-6-one

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

Prepared by reacting 20.00 g of guanosine-hydrate with 22.54 g of 2-cyano-benzylbromide in dimethylsulphoxide at 60° C. and subsequent treatment with 57 ml of conc. hydrochloric acid.

Workup

  1. customPrepared
  2. customat 60° C.

Sources & evidence

ORD record
ord-9626b5ed14ec474db812289f305bbb41
Source dataset
uspto-grants-2016_04
Patent number
US09321791B2

Reaction notes

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