反应详情

6.62 mL (47.26 mmol) of triethylamine and 8.26 g (43.32 mmol) of 4-methylbenzenesulfonyl chloride are added at 0° C. to a solution of 5 g (39.38 mmol) of 2-pyrid-3-ylethanol in 300 mL of dichloromethane. After allowing the reaction medium to warm to room temperature and stirring overnight, it is washed with water and with saturated NaCl solution. The organic phase is dried over magnesium sulfate and evaporated to dryness. After purification by chromatography on silica gel (eluent: 4/6 heptane/EtOAc), 8 g of 2-pyrid-3-ylethyl toluene-4-sulfonate were obtained, corresponding to the following characteristics:

1. washit is washed with water and with saturated NaCl solution
2. dry with materialThe organic phase is dried over magnesium sulfate
3. customevaporated to dryness
4. customAfter purification by chromatography on silica gel (eluent: 4/6 heptane/EtOAc)