Hydrogen Bromide → 2-bromo-1-(6-methoxypyrid-3-yl)ethanone hydrobromide

HRID 633753Notes

Reaction equation

HRID 633753 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][CH:4]=1.[BrH:12].BrBr>C(O)(=O)C>[BrH:12].[Br:12][CH2:10][C:9]([C:6]1[CH:7]=[N:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)=[O:11]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 105348375-Acetyl-2-methoxypyridine

Product 1

HCID 879433972-bromo-1-(6-methoxypyrid-3-yl)ethanone hydrobromide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

230 mg (1.52 mmol) of 1-(6-methoxypyrid-3-yl)ethanone, 413 μl (7.61 mmol) of hydrobromic acid, 87 μl (1.67 mmol) of bromine and 5 mL of glacial acetic acid were used in the reaction. After precipitation with ethyl ether and filtration, 430 mg of 2-bromo-1-(6-methoxypyrid-3-yl)ethanone hydrobromide are obtained, the characteristics of which are as follows:

Workup

  1. customAfter precipitation
  2. filtrationwith ethyl ether and filtration, 430 mg of 2-bromo-1-(6-methoxypyrid-3-yl)ethanone hydrobromide
  3. customare obtained

Sources & evidence

ORD record
ord-2a65da26f5064c17b78872675916a922
Source dataset
uspto-grants-2016_04
Patent number
US09321790B2

Reaction notes

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