Hydrogen Bromide → HCID 131735475, compound

HRID 633755Notes

Reaction equation

HRID 633755 reaction equation
[F:1][CH2:2][CH2:3][O:4][C:5]1[N:10]=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[CH:7][CH:6]=1.[BrH:14].BrBr>C(O)(=O)C>[BrH:14].[Br:14][CH2:12][C:11]([C:8]1[CH:9]=[N:10][C:5]([O:4][CH2:3][CH2:2][F:1])=[CH:6][CH:7]=1)=[O:13]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 586290251-[6-(2-Fluoroethoxy)-3-pyridinyl]ethanone

Product 1

HCID 131735475HCID 131735475, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

362 mg (1.98 mmol) of 1-[6-(2-fluoroethoxy)pyrid-3-yl]ethanone, 413 μl (7.61 mmol) of hydrobromic acid, 537 μl (9.88 mmol) of bromine and 5 mL of glacial acetic acid were used in the reaction. After precipitation with ethyl ether and filtration, 602 mg of 2-bromo-1-[6-(2-fluoroethoxy)pyrid-3-yl]ethanone hydrobromide are obtained, the characteristics of which are as follows:

Workup

  1. customAfter precipitation
  2. filtrationwith ethyl ether and filtration, 602 mg of 2-bromo-1-[6-(2-fluoroethoxy)pyrid-3-yl]ethanone hydrobromide
  3. customare obtained

Sources & evidence

ORD record
ord-87df87d8c7344fab8c9ce21cedeeb4d3
Source dataset
uspto-grants-2016_04
Patent number
US09321790B2

Reaction notes

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