Ethanol → HCID 18715057, compound

HRID 633764Notes

Reaction equation

HRID 633764 reaction equation
C(O)C.Cl[C:5]1[N:10]=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[CH:7][CH:6]=1.[CH3:14][NH2:15]>C1COCC1>[CH3:14][NH:15][C:5]1[N:10]=[CH:9][C:8]([C:11](=[O:13])[CH3:12])=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 6329MethylamineHCID 27796981-(6-Chloropyridin-3-yl)ethan-1-one

Product 1

HCID 18715057HCID 18715057, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 2 mL of ethanol, 280 mg (1.80 mmol) of 1-(6-chloropyrid-3-yl)ethanone and 4.50 mL (9 mmol) of a 2 M solution of methylamine in THF is heated in a Biotage microwave reactor at 130° C. for 30 minutes. The reaction medium is evaporated to dryness. The crude product is taken up in water and extracted with EtOAc. The organic phase is dried over magnesium sulfate and evaporated to dryness. 258 mg of 1-(6-methylaminopyrid-3-yl)ethanone are obtained, the characteristics of which are as follows:

Workup

  1. customThe reaction medium is evaporated to dryness
  2. extractionextracted with EtOAc
  3. dry with materialThe organic phase is dried over magnesium sulfate
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-adf07c0bb255489daf7176ac3369c637
Source dataset
uspto-grants-2016_04
Patent number
US09321790B2

Reaction notes

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