Phenylboronic Acid → HCID 118131246, compound

HRID 634373Notes

Reaction equation

HRID 634373 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[C:5](=[O:13])[O:4][C:3]=1[CH:14]([OH:16])[CH3:15].[C:17]1(B(O)O)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[C:3]([CH:14]([OH:16])[CH3:15])[O:4][C:5]2=[O:13])=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 118131269HCID 118131269, compound2×

Product 1

HCID 118131246HCID 118131246, compoundYield 38.9%

Procedure

The title compound was made in a similar way of that of Intermediate B53 from 4-bromo-7-chloro-3-(1-hydroxyethyl)-1H-isochromen-1-one (intermediate A5, 1.4 g, 4.61 mmol) and phenylboronic acid (0.844 g, 6.92 mmol) to afford title compound as a yellow foam (0.540 g) which was used without any additional purification.

Sources & evidence

ORD record
ord-da99c91a399e43a99a242eb1a5f7d68d
Source dataset
uspto-grants-2016_04
Patent number
US09321776B2

Reaction notes

Loading…