Phenylboronic Acid → HCID 118131321, compound

HRID 634374Notes

Reaction equation

Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([Cl:12])[CH:10]=2)[C:5](=[O:13])[O:4][C:3]=1[CH:14]([OH:16])[CH3:15].[C:17]1(B(O)O)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[Cl:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[C:5](=[O:13])[O:4][C:3]([CH:14]([OH:16])[CH3:15])=[C:2]2[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

Reactant 2

HCID 66827Phenylboronic Acid

HCID 118131311HCID 118131311, compound2×

Product 1

HCID 118131321HCID 118131321, compoundYield 45%

Procedure

The title compound was made in a similar way of that of Intermediate B53 from 4-bromo-6-chloro-3-(1-hydroxyethyl)-1H-isochromen-1-one (intermediate A6, 0.973 g, 3.205 mmol) and phenylboronic acid (0.586 g, 4.808 mmol) to yield title compound as a white foam (0.430 g, 1.43 mmol, 45%).

Sources & evidence

ORD record: ord-3da013b1392343a7bab7405e039e7dab
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09321776B2

Reaction notes

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