Phenylboronic Acid → HCID 118131122, compound

HRID 634375Notes

Reaction equation

HRID 634375 reaction equation
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([F:12])[CH:10]=2)[C:5](=[O:13])[O:4][C:3]=1[CH:14]([OH:16])[CH3:15].[C:17]1(B(O)O)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[C:5](=[O:13])[O:4][C:3]([CH:14]([OH:16])[CH3:15])=[C:2]2[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 118131055HCID 118131055, compound2×

Product 1

HCID 118131122HCID 118131122, compoundYield 78.2%

Procedure

The title compound was made in a similar way of that of Intermediate B53 from 4-bromo-6-fluoro-3-(1-hydroxyethyl)-1H-isochromen-1-one (intermediate A7, 0.95 g, 3.31 mmol) and phenylboronic acid (0.605 g, 4.96 mmol) to afford title compound (0.736 g) which was used without any additional purification.

Sources & evidence

ORD record
ord-7ee30bbedbc84e44b306a0b4c482d824
Source dataset
uspto-grants-2016_04
Patent number
US09321776B2

Reaction notes

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