Potassium Carbonate → HCID 178424545, compound

HRID 634442Notes

Reaction equation

HRID 634442 reaction equation
[N:1]1[C:9]([S:10]CC2OC(=O)C3C(C=2C2C=CC=CC=2)=CC=CC=3)=[C:8]2[C:4]([NH:5][CH:6]=[N:7]2)=[N:3][CH:2]=1.Br[CH:30]([C:32]1[O:33][C:34](=[O:49])[C:35]2[C:40]([C:41]=1[C:42]1[CH:43]=[C:44]([CH3:48])[CH:45]=[CH:46][CH:47]=1)=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH3:31].O.N1C(S)=C2C(NC=N2)=NC=1.C([O-])([O-])=O.[K+].[K+]>>[N:1]1[C:9]([S:10][CH:30]([C:32]2[O:33][C:34](=[O:49])[C:35]3[C:40]([C:41]=2[C:42]2[CH:43]=[C:44]([CH3:48])[CH:45]=[CH:46][CH:47]=2)=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH3:31])=[C:8]2[C:4]([NH:5][CH:6]=[N:7]2)=[N:3][CH:2]=1

Participants

5

Reactant 4

HCID 11430Potassium CarbonateHCID 1181310323-(1-Bromoethyl)-4-m-tolyl-1H-isochromen-1-one2×HCID 178519204HCID 178519204, compoundHCID 178527205HCID 178527205, compound

Product 1

HCID 178424545HCID 178424545, compoundYield 87%

Procedure

The title compound was made in a similar way as that of the compound of example 10, 3-(1-bromoethyl)-4-m-tolyl-1H-isochromen-1-one (intermediate C5, 67 mg, 0.195 mmol), 9H-purine-6-thiol hydrate (33.2 mg, 0.195 mmol)) and K2CO3 (27 mg, 0.111 mmol) to give to give the title compound (70 mg, 87%)

Workup

  1. customto give

Sources & evidence

ORD record
ord-9bb4d5169ba741929e95dbe9a342b3be
Source dataset
uspto-grants-2016_04
Patent number
US09321776B2

Reaction notes

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