反应详情

Boron tribromide (3.1 ml, 3.2 mmol) was added to a solution of 2,4-dimethoxytoluene (1 g, 6.5 mmol) in pentane (10 ml) at −70° C. The reaction mixture was allowed to warm to ambient temperature and the mixture stirred for a further 2 hours. Ice water and ethyl acetate were then added and the aqueous layer basified to pH9.5 with 2M aqueous sodium hydroxide. After stirring for 10 minutes, the organic layer was separated and the aqueous layer extracted with ethyl acetate. The combined organic extract was washed with brine, dried (MgSO4) and the solvent removed by evaporation. The residue was purified by flash chromatography eluting with methylene chloride/ethyl acetate (9/1) to give 2,4-dihydroxytoluene (759 mg, 94%) as a white solid.

1. stirringAfter stirring for 10 minutes
2. customthe organic layer was separated
3. extractionthe aqueous layer extracted with ethyl acetate
4. extractionThe combined organic extract
5. washwas washed with brine
6. dry with materialdried (MgSO4)
7. customthe solvent removed by evaporation
8. customThe residue was purified by flash chromatography
9. washeluting with methylene chloride/ethyl acetate (9/1)