反应详情

温度

85 °C

1,2-Dibromoethane (1.6 ml, 18.6 mmol) was added to 7-hydroxy-6-methoxy-4-phenoxyquinazoline (0.5 g, 1.86 mmol), (prepared as described for the starting material in Example 16), and potassium carbonate (1.2 g, 8.7 mmol) in DMF (60 ml) and the mixture was heated at 85° C. for 2 hours, and was then allowed to cool. The insolubles were removed by filtration, and the volatiles were removed from the filtrate by evaporation to give a residue which was purified by column chromatography eluting with methylene chloride/methanol (97/3) to give 7-(2-bromoethoxy)-6-methoxy-4-phenoxyquinazoline (440 mg, 63%).

1. custom(prepared
2. temperatureto cool
3. customThe insolubles were removed by filtration
4. customthe volatiles were removed from the filtrate by evaporation
5. customto give a residue which
6. customwas purified by column chromatography
7. washeluting with methylene chloride/methanol (97/3)