反应详情

温度

95 °C

A mixture of 6-methoxy,7-(2-(4-methylpiperazin-1-yl)ethoxy)-4-phenoxyquinazoline (960 mg, 2.4 mmol) and 2M hydrochloric acid (20 ml) was heated at 95° C. for 2 hours and allowed to cool. The solution was basified with solid sodium hydrogen carbonate, the water removed by evaporation and the residue azeotroped with toluene. The residue was washed exhaustively with methylene chloride, the washings were combined, -insolubles removed by filtration and the solvent removed by evaporation to give 6-methoxy-7-(2-(4-methylpiperazin-1-yl)ethoxy)-3,4-dihydroquinazolin-4-one (500 mg, 66%).

1. temperatureto cool
2. customthe water removed by evaporation
3. customthe residue azeotroped with toluene
4. washThe residue was washed exhaustively with methylene chloride
5. custom-insolubles removed by filtration
6. customthe solvent removed by evaporation