反应详情

温度

110 °C

1-(2-Chloroethyl)piperidine hydrochloride (0.83 g, 4.5 mmol) was added to 7-hydroxy-6-methoxy-4-phenoxyquinazoline (1.0 g, 3.73mmol), (prepared as described for the starting material in Example 16), and potassium carbonate (2.6 g, 18.8 mmol) in DMF (30 ml), and the mixture heated at 110° C. for 2.5 hours and allowed to cool. The insolubles were removed by filtration, and the volatiles were removed from the filtrate by evaporation. The residue was purified by column chromatography eluting with methylene chloride/methanol (9/1) to give 6-methoxy-4-phenoxy-7-(2-piperidinoethoxy)quinazoline (1.2 g, 85%).

1. custom(prepared
2. temperatureto cool
3. customThe insolubles were removed by filtration
4. customthe volatiles were removed from the filtrate by evaporation
5. customThe residue was purified by column chromatography
6. washeluting with methylene chloride/methanol (9/1)