反应详情

温度

90 °C

A mixture of 6-methoxy-4-phenoxy-7-(2-thiomorpholinoethoxy)quinazoline (2.0 g, 5 mmol) in 2M hydrochloric acid (25 ml) was heated at 90° C. for 1.5 hours. The mixture was allowed to cool and adjusted to pH7 with solid sodium hydrogen carbonate. Methylene chloride was added and the resulting semi-solid product was isolated by decanting and filtering the aqueous mixture. This product was dissolved in acetone and insoluble material was removed by filtration. The solvent was removed by evaporation and the residue azeotroped with toluene to give 6-methoxy-7-(2-thiomorpholinoethoxy)-3,4-dihydroquinazolin-4-one (1.5 g, 92%) as a white solid.

1. temperatureto cool
2. customthe resulting semi-solid product was isolated
3. customby decanting
4. filtrationfiltering the aqueous mixture
5. dissolutionThis product was dissolved in acetone
6. custominsoluble material was removed by filtration
7. customThe solvent was removed by evaporation
8. customthe residue azeotroped with toluene