反应详情

温度

90 °C

A mixture of 6-methoxy-4-phenoxy-7-(2-(2-methoxyethylamino)ethoxy)quinazoline (760 mg, 2 mmol) in 2M hydrochloric acid (5 ml) was heated at 90° C. for 1.5 hours. The mixture was allowed to cool and adjusted to pH7 with solid sodium hydrogen carbonate. The water was removed by evaporation and the residue extracted with methylene chloride/methanol/aqueous ammonia (100/8/1). The volatiles were removed from the extract by evaporation, the residue dissolved in methylene chloride, passed through phase separating paper and the solvent removed by evaporation to give 6-methoxy-7-(2-(2-methoxyethylamino)ethoxy)-3,4-dihydroquinazolin-4-one (600 mg, 99%) as a white solid.

1. temperatureto cool
2. customThe water was removed by evaporation
3. extractionthe residue extracted with methylene chloride/methanol/aqueous ammonia (100/8/1)
4. customThe volatiles were removed from the
5. extractionextract by evaporation
6. dissolutionthe residue dissolved in methylene chloride
7. customseparating paper
8. customthe solvent removed by evaporation