Potassium Iodide → HCID 15451100, compound

HRID 634907Notes

Reaction equation

HRID 634907 reaction equation
C(N(CC)C(C)C)(C)C.Br[CH2:11][CH2:12][OH:13].[I-].[K+].[CH3:16][C:17]1([CH3:30])[CH:26]=[C:25]([CH3:27])[C:24]2[C:19](=[CH:20][C:21]([O:28][CH3:29])=[CH:22][CH:23]=2)[NH:18]1>>[OH:13][CH2:12][CH2:11][N:18]1[C:19]2[C:24](=[CH:23][CH:22]=[C:21]([O:28][CH3:29])[CH:20]=2)[C:25]([CH3:27])=[CH:26][C:17]1([CH3:30])[CH3:16]

Participants

5

Reactant 4

HCID 4875Potassium IodideHCID 108982-BromoethanolHCID 81531DiisopropylethylamineHCID 6434787-methoxy-2,2,4-trimethyl-1,2-dihydroquinoline

Product 1

HCID 15451100HCID 15451100, compound

Conditions

Temperature
115 °C

Procedure

51 g (0.4 mol) N,N-diisopropylethylamine, 72.5 g (0.57 mol) 2-bromoethanol and a spatula tip of potassium iodide were added to 50 g (0.24 mol) 2,2,4-trimethyl-7-methoxy-1,2-dihydroquinoline. The solution was stirred for 24 hours at 110 to 120° C. The organic phase was subsequently washed with dilute sodium hydroxide solution and water and dried over sodium sulfate. The solvent was then completely removed by distillation. A light-green oil was obtained as the product.

Workup

  1. washThe organic phase was subsequently washed with dilute sodium hydroxide solution and water
  2. dry with materialdried over sodium sulfate
  3. customThe solvent was then completely removed by distillation
  4. customA light-green oil was obtained as the product

Sources & evidence

ORD record
ord-62dbb1ac70914955bd450e70a52eac23
Source dataset
uspto-grants-2001_02
Patent number
US06184379B2

Reaction notes

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