反应详情

Ethyl acetoacetate (100 g, 0.77 mol) was dissolved in acetone (500 ml). To the thus obtained solution was added dibromoethane (361 g, 1.92 mol) and potassium carbonate (266 g, 1.92 mol) and the mixture was heated under reflux for 4 days. After filtering off insoluble matter, the filtrate was distilled under reduced pressure (80° C./8 mmHg) to obtain 78.1 g (65.1%) of the title compound as a colorless oily substance.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 4 days
3. filtrationAfter filtering off insoluble matter
4. distillationthe filtrate was distilled under reduced pressure (80° C./8 mmHg)