1-(4-Chlorophenyl)piperazine → 4-(4-Chlorophenyl)piperidine

HRID 635312Notes

Reaction equation

HRID 635312 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](N2CCNCC2)=[CH:4][CH:3]=1.N1[NH:15][C:16](CCC(O)=O)=[C:17]2C=1C[CH2:20][CH2:19][CH2:18]2>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:18]2[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 974781-(4-Chlorophenyl)piperazineHCID 1785253693-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propanoic acid

Product 1

HCID 12036134-(4-Chlorophenyl)piperidine

Procedure

In the same manner as in Example 102 except that 3-(5-benzoyl-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-3-yl)propionic acid obtained in Starting Material Synthesis Example 8 and 1-(4-chlorophenyl)piperazine were used instead of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid obtained in Stating Material Synthesis Example 1 and 4-(4-chlorophenyl)piperidine, 5-benzyl-3-(3-(4-(4chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine was obtained.

Sources & evidence

ORD record
ord-ffea1de8435646fcbc941d4eb0a7722f
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Reaction notes

Loading…