1-(4-Chlorophenyl)piperazine → HCID 17773079, compound

HRID 635322Notes

Reaction equation

HRID 635322 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[N:14]1[NH:15][C:16]([CH2:23][CH2:24][C:25](O)=O)=[C:17]2[C:22]=1[CH2:21][CH2:20][CH2:19][CH2:18]2.[Cl:28][C:29]1[CH:34]=[CH:33][C:32](C2CCNCC2)=[CH:31][CH:30]=1>>[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([N:15]2[C:16]([CH2:23][CH2:24][CH2:25][N:11]3[CH2:12][CH2:13][N:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)[CH2:9][CH2:10]3)=[C:17]3[C:22]([CH2:21][CH2:20][CH2:19][CH2:18]3)=[N:14]2)=[CH:31][CH:30]=1

Participants

4

Reactant 3

HCID 974781-(4-Chlorophenyl)piperazineHCID 12036134-(4-Chlorophenyl)piperidineHCID 1785253693-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propanoic acid

Product 1

HCID 17773079HCID 17773079, compound

Procedure

In the same manner as in Example 102 except that 3-(2-(4-chlorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid obtained in Starting Material Synthesis Example 12 and 1-(4-chlorophenyl)piperazine were used instead of 3-(4,5,6,7-tetrahydro-2H-indazol-3-yl)propionic acid obtained in Starting Material Synthesis Example 1 and 4-(4-chlorophenyl)piperidine, 2-(4-chlorophenyl)-3-(3-(4-(4-chlorophenyl)piperazin-1-yl)propyl)-4,5,6,7-tetrahydro-2H-indazole was obtained, m.p. 129-131° C.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-c303993aaabf4952885b807ad68642d5
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Reaction notes

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