反应详情

A mixture of 1.62 g of 3-methyl-4-nitroimino-perhydro-1,3,5-oxadiazine, 2.44 g of 2-chloro-5-chloromethyl-thiazole, 4.2 g of potassium carbonate and 25 ml of N,N-dimethylformamide is heated for 5 h at 60° and then filtered. The filtrate is evaporated in vacuo on a rotary evaporator, and the residue is purified by chromatography [silica gel; dichloromethane/methanol (95:5)]. This gives the title compound, which melts at 132-134°, in a yield of 67%.

1. temperatureis heated for 5 h at 60°
2. filtrationfiltered
3. customThe filtrate is evaporated in vacuo on a rotary evaporator
4. customthe residue is purified by chromatography [silica gel; dichloromethane/methanol (95:5)]