1,1-Dichloroethane → HCID 86756417, compound

HRID 635539Notes

Reaction equation

HRID 635539 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[C:12]([OH:23])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]([F:22])([F:21])[F:20])[C:10]#[N:11].ClC(Cl)C.[CH3:28][S:29](Cl)(=[O:31])=[O:30]>C(N(CC)CC)C>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=[C:12]([O:23][S:29]([CH3:28])(=[O:31])=[O:30])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:19]([F:20])([F:21])[F:22])[C:10]#[N:11]

Participants

5

Reactant 3

HCID 63651,1-DichloroethaneHCID 31297Methanesulfonyl chlorideHCID 69978536HCID 69978536, compound

Product 1

HCID 86756417HCID 86756417, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

93 mg of triethylamine was added to a mixture comprising 0.30 g of α-(2,4-dichlorophenyl)-β-hydroxy-β-(2-trifluoromethylphenyl)acrylonitrile and 7 ml of dichloroethane. Then, 96 mg of methanesulfonyl chloride was added thereto, and the mixture was reacted for 17 hours at room temperature.

Workup

  1. customthe mixture was reacted for 17 hours at room temperature

Sources & evidence

ORD record
ord-b230da4b18f440b294a1d8f3df50d5fe
Source dataset
uspto-grants-2001_02
Patent number
US06187944B1

Reaction notes

Loading…