1,1-Dichloroethane → HCID 86756418, compound

HRID 635540Notes

Reaction equation

HRID 635540 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[C:11]([OH:22])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([F:21])([F:20])[F:19])[C:9]#[N:10])=[CH:4][CH:3]=1.ClC(Cl)C.[CH2:27]([S:30](Cl)(=[O:32])=[O:31])[CH2:28][CH3:29]>C(N(CC)CC)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[C:11]([O:22][S:30]([CH2:27][CH2:28][CH3:29])(=[O:32])=[O:31])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([F:20])([F:21])[F:19])[C:9]#[N:10])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 63651,1-Dichloroethane2×HCID 662791-Propanesulfonyl chlorideHCID 69976425HCID 69976425, compound

Product 1

HCID 86756418HCID 86756418, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

60 mg of triethylamine was added to a mixture comprising 0.20 g of α-(4-bromophenyl)-β-hydroxy-β-(2-trifluoromethylphenyl)acrylonitrile and 6 ml of dichloroethane. Then, a mixture comprising 77 mg of n-propanesulfonyl chloride and 2 ml of dichloroethane, was dropwise added thereto. After completion of the dropwise addition, the mixture was reacted for 15 hours at room temperature.

Workup

  1. additionAfter completion of the dropwise addition
  2. customthe mixture was reacted for 15 hours at room temperature

Sources & evidence

ORD record
ord-15ea409c747845998c44820429260939
Source dataset
uspto-grants-2001_02
Patent number
US06187944B1

Reaction notes

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