Hydrochloric Acid → 2-Chloro-1-phenylethanol, (+)-

Temperature

50 °C

To a slurry solution of 143 mg (0.5 mmol) of (R)-1,1′-bi-2-naphthol in 10 ml of toluene was added 102 mg (0.5 mmol) of aluminum triisopropoxide at room temperature, and the mixture was stirred at room temperature for 20 minutes and further at 50° C. for 1 hour. Thereto 1.52 ml (20 mmol) of 2-propanol was added and the mixture was stirred further at room temperature for 30 minutes. Thereto 1.55 g (10 mmol) of phenacyl chloride was added and the mixture was further stirred at 50° C. for 4 hours. To the mixture were added 2 ml of 1N hydrochloric acid and 20 ml of water to conduct hydrolysis. The mixture was extracted with ethyl acetate and concentrated to obtain an oily product. The after-treatment and the analysis of the product were then carried out in the same manner as described in Example 2.

1. stirringthe mixture was stirred further at room temperature for 30 minutes
2. stirringthe mixture was further stirred at 50° C. for 4 hours
3. customhydrolysis
4. extractionThe mixture was extracted with ethyl acetate
5. concentrationconcentrated
6. customto obtain an oily product

ORD record

ord-c6efd2ff1c484c3cbab5dbf8a7a0a91c

Source dataset

uspto-grants-2001_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06187966B1