Triethylamine → HCID 178428562, compound

HRID 635803Notes

Reaction equation

HRID 635803 reaction equation
[N:1]1([C@H:7]2[CH2:12][CH2:11][C@H:10]([OH:13])[CH2:9][CH2:8]2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:15]1[N:20]=[C:19]([CH3:21])[CH:18]=[CH:17][N:16]=1.C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH3:21][C:19]1[CH:18]=[CH:17][N:16]=[C:15]([N:4]2[CH2:3][CH2:2][N:1]([C@H:7]3[CH2:8][CH2:9][C@H:10]([OH:13])[CH2:11][CH2:12]3)[CH2:6][CH2:5]2)[N:20]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 116296072-Chloro-4-methylpyrimidineHCID 178521570HCID 178521570, compound

Product 1

HCID 178428562HCID 178428562, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The compound 10a (4.3 g, 23.3 mmol) is placed in 100 ml of toluene in the presence of 2-chloro-4-methylpyrimidine (3 g, 23.3 mmol) and of triethylamine (4.9 ml, 35.1 mmol) and then this mixture is heated at reflux for 16 h.

Workup

  1. temperaturethis mixture is heated
  2. temperatureat reflux for 16 h.

Sources & evidence

ORD record
ord-3c057c410ef8429f9e6d1857a2996c85
Source dataset
uspto-grants-2001_02
Patent number
US06191130B1

Reaction notes

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