反应详情

(Step 1) To 1.3 L (liters) of dry tetrahydrofuran (THF) was added 162 g of 60% sodium hydride (NaH) and 342 g of diethyl carbonate. To this mixture was added a solution of 200 g p-fluoroacetophenone in 440 ml dry THF dropwise over about 1 hour while refluxing, followed by 6 hours of refluxing. This reaction mixture was cooled, poured into iced water, neutralized with concentrated hydrochloric acid, and extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate (MgSO4), and concentrated. The residue was distilled under reduced pressure to provide 291 g of ethyl 3-(4-fluorophenyl)-3-oxopropionate as pale yellow oil.

1. temperaturewhile refluxing
2. temperatureof refluxing
3. temperatureThis reaction mixture was cooled
4. extractionextracted with ethyl acetate
5. washThe organic layer was washed with water
6. dry with materialdried over anhydrous magnesium sulfate (MgSO4)
7. concentrationconcentrated
8. distillationThe residue was distilled under reduced pressure