反应详情

温度

22 °C

20 g (0.0693 mol) of 95% pure 3-fluoro-2-phenylthio-5-trifluoromethylpyridine were introduced into 100 ml of glacial acetic acid and 20 ml of trifluoroacetic acid and over a period of 5 min, with stirring at 22° C., 5.64 g (0.083 mol) of 50% strength hydrogen peroxide were added. The reaction mixture was stirred at 22° C. for 10 h and then poured into 1 l of ice-water and extracted with methylene chloride. The organic phase was washed with saturated sodium bicarbonate solution and water. After drying, filtration through silica gel and concentration under reduced pressure, 19.1 g (95.4% of theory) of the title compound of 24 n D

1. stirringThe reaction mixture was stirred at 22° C. for 10 h
2. extractionextracted with methylene chloride
3. washThe organic phase was washed with saturated sodium bicarbonate solution and water
4. customAfter drying
5. filtrationfiltration
6. concentrationthrough silica gel and concentration under reduced pressure, 19.1 g (95.4% of theory) of the title compound of 24 n D