反应详情

10 ml of a 33% solution of methylamine in EtOH was added to a solution of 0.3 g (0.85 mmol) of 3-benzenesulphonyl-7-chloro-5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidine in 5 ml of DMF and stirred at RT for 2 hrs. The reaction solution was evaporated in a high vacuum and the residue was partitioned between 2N NaOH and CH2Cl2. The aqueous phase was extracted three times with CH2Cl2, and the combined organic phases were dried (MgSO4), filtered and evaporated. Subsequent chromatography (SiO2,CH2Cl2/AcOEt 15:1) and crystallization from EtOH yielded 0.18 g (60%) of (3-benzenesulphonyl 5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidin-7-yl)-methyl-amine as colorless crystals, m.p. >230°.

1. customThe reaction solution was evaporated in a high vacuum
2. customthe residue was partitioned between 2N NaOH and CH2Cl2
3. extractionThe aqueous phase was extracted three times with CH2Cl2
4. dry with materialthe combined organic phases were dried (MgSO4)
5. filtrationfiltered
6. customevaporated
7. customSubsequent chromatography (SiO2,CH2Cl2/AcOEt 15:1) and crystallization from EtOH