反应详情

To a solution of 3-nitrobenzene-1,2-diol (2.78 g) and 3,4-dihydro-2H-pyrane (1.81 g) in benzene (39 ml) was added p-toluenesulfonic acid monohydrate (5 mg) at ambient temperature, and the mixture was stirred for 24 hours. The reaction mixture was washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by silica gel column chromatography (chloroform—methanol) and crystallized with n-hexane to give 2-nitro-6-(tetrahydropyran-2-yloxy)phenol (2.32 g).

1. washThe reaction mixture was washed with saturated sodium bicarbonate solution
2. dry with materialdried over magnesium sulfate
3. customevaporated in vacuo
4. customThe residue was purified by silica gel column chromatography (chloroform—methanol)
5. customcrystallized with n-hexane