Tert-Butylamine → HCID 21255693, compound

HRID 636740Notes

Reaction equation

HRID 636740 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:11]([NH2:15])([CH3:14])([CH3:13])[CH3:12]>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH:4]=[N:15][C:11]([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 6385Tert-Butylamine2×HCID 737702,4-Difluorobenzaldehyde

Product 1

HCID 21255693HCID 21255693, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of 2,4-difluorobenzaldehyde (431.6 mg, 3.04 mmol) in toluene (5 ml) was added t-butylamine (0.63 ml, 6.00 mmol) and stirred under reflux using a Dean-Stark trap to remove water for 1 hour. Then t-butylamine (0.63 ml, 6.00 mmol) was added to the mixture and stirred for 5 hours. The solvent was evaporated to give the title compound.

Workup

  1. temperatureunder reflux
  2. customto remove water for 1 hour
  3. stirringstirred for 5 hours
  4. customThe solvent was evaporated

Sources & evidence

ORD record
ord-29be1c2f3e1e4be6a748d171bdb800ed
Source dataset
uspto-grants-2001_02
Patent number
US06194461B1

Reaction notes

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