反应详情

To a solution of 4.7 gm of (R)-(−)-2-phenylbutanol (31.78 mmol) and 7.6 mL of pyridine (95 mmol) in 40 mL of CH2Cl2 was added 10 gm of methanesulfonic anhydride (64 mmol). After stirring at room temperature for 5 hr, 100 mL of water was added and the mixture was extracted 3 times with ether. The combined organic fractions were washed with 1N HCl, sat. NaHCO3 and sat. NaCl solutions. The organic fractions were dried over MgSO4, filtered through a thin layer of silica and concentrated in vacuo. The methanesulfonate was used without further purification. 1H NMR (CDCl3) δ 0.85 (t, 3H), 1.65 (m, 2H), 1.85 (m, 2H), 2.75 (s, 3H), 2.9 (m, 1H), 4.35 (d, 2H), 7.3 (m, 5H). A solution of the methanesulfonate, 10 gm of sodium azide (154 mmol) and a trace amount of sodium iodide in 50 mL of DMF was stirred at 80° C. for 12 hr. The reaction mixture was then cooled and 200 mL of ether was added. The mixture was washed 3 times with water, then with sat. NaCl solution, dried over MgSO4, filtered and concentrated. To a solution of the azide in 20 mL of THF was added 50 mL of a 1M solution of LAH in THF and the reaction mixture was stirred at room temperature. After 2 hours, the reaction was quenched with successive additions of 5 mL of water, 5 mL of 10% KOH and 5 mL of water. The aluminum salts were removed by filtration and washed with 200 mL of ethylacetate. The filtrate was dried over MgSO4, filtered and concentrated. The residue was purified by vacuum distillation in a Kugelrohr apparatus (bp 145° C., 0.2 Torr) to give the title compound as a clear liquid.

1. extractionthe mixture was extracted 3 times with ether
2. washThe combined organic fractions were washed with 1N HCl, sat. NaHCO3 and sat. NaCl solutions
3. dry with materialThe organic fractions were dried over MgSO4
4. filtrationfiltered through a thin layer of silica
5. concentrationconcentrated in vacuo
6. customThe methanesulfonate was used without further purification
7. temperatureThe reaction mixture was then cooled
8. washThe mixture was washed 3 times with water
9. dry with materialwith sat. NaCl solution, dried over MgSO4
10. filtrationfiltered
11. concentrationconcentrated
12. additionTo a solution of the azide in 20 mL of THF was added 50 mL of a 1M solution of LAH in THF
13. stirringthe reaction mixture was stirred at room temperature
14. waitAfter 2 hours
15. customthe reaction was quenched with successive additions of 5 mL of water, 5 mL of 10% KOH and 5 mL of water
16. customThe aluminum salts were removed by filtration
17. washwashed with 200 mL of ethylacetate
18. dry with materialThe filtrate was dried over MgSO4
19. filtrationfiltered
20. concentrationconcentrated
21. distillationThe residue was purified by vacuum distillation in a Kugelrohr apparatus (bp 145° C., 0.2 Torr)