反应详情

4-Amino-2-(ethoxymethyl)-α,α-dimethyl-1H-Imidazo[4,5-c]quinoline-1-ethanol (CAN 144875-48-9, 1.6 g, 5.09 mmol) was combined with acetonitrile (60 mL) to give a white suspension. Then triethylamine (1.77 mL, 12.7 mmol) and trityl chloride (1.7 g, 6.11 mmol) were added under Argon with stirring. The reaction mixture was irradiated in a microwave reactor at 100° C. for 30 minutes. Upon stirring the mixture the product precipitated and was isolated by filtration at 0° C., washed with cold acetonitrile and dried to yield the title compound (2.37 g, 83%) as white solid; MS (ESI): 557.5(MH+).

1. customto give a white suspension
2. customThe reaction mixture was irradiated in a microwave reactor at 100° C. for 30 minutes
3. stirringUpon stirring the mixture the product
4. customprecipitated
5. customwas isolated by filtration at 0° C.
6. washwashed with cold acetonitrile
7. customdried