Methanol → HCID 53638471, compound

HRID 637257Notes

Reaction equation

HRID 637257 reaction equation
[CH3:1][C@H:2]([NH:9][C:10]([C:12]1[C:13]([CH3:21])=[N:14][C:15]([CH3:20])=[C:16]([CH2:18]Cl)[CH:17]=1)=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Na].[CH3:23][OH:24]>>[CH3:1][C@H:2]([NH:9][C:10]([C:12]1[C:13]([CH3:21])=[N:14][C:15]([CH3:20])=[C:16]([CH2:18][O:24][CH3:23])[CH:17]=1)=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 887Methanol2×HCID 5360545SodiumHCID 15591551HCID 15591551, compound

Product 1

HCID 53638471HCID 53638471, compound

Procedure

In a 250 ml round-bottomed flask, (S)-3-[N-(α-methylbenzyl)-carbamoyl]-5-chloromethyl-2,6-dimethylpyridine (21 g), the preparation of which is described in Example 6, is introduced into anhydrous methanol (50 ml). After dissolution, a solution of sodium (5.00 g) in methanol (50 ml) is run in.

Workup

  1. dissolutionAfter dissolution

Sources & evidence

ORD record
ord-5338aea264ad49458703a72c48a99cfd
Source dataset
uspto-grants-1985_12
Patent number
US04556414

Reaction notes

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