反应详情

To a solution of 194 mg (1.0 mmole) of 2-(2-ureidophenyl)acetic acid in 4 ml of trifluoroacetic acid was added 630 mg (3.0 mmole) of trifluoroacetic anhydride, and the mixture was then heated under reflux for ca. 1 hour. The reaction mixture was cooled and the solvent was removed by evaporation in vacuo. The residue was triturated under 5-8 ml of saturated sodium bicarbonate solution, and the material which remained out of solution was collected by filtration. The solid thus obtained was recrystallized from ethanol to give 61 mg of the title compound as colorless needles, m.p. 179°-180° C. (slight decomposition).

1. temperaturethe mixture was then heated
2. temperatureunder reflux for ca. 1 hour
3. temperatureThe reaction mixture was cooled
4. customthe solvent was removed by evaporation in vacuo
5. customThe residue was triturated under 5-8 ml of saturated sodium bicarbonate solution
6. filtrationwas collected by filtration
7. customThe solid thus obtained
8. customwas recrystallized from ethanol